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Oxidative stress and inflammation are major contributors to premature skin aging, leading to the formation of fine lines, wrinkles, and uneven skin tone

Similarly, in 5FAD transgenic mice, GPX4 overexpression improves cognition, reduces neurodegeneration, lowers LPO levels, and decreases A production (300)

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doi:10.1038/ncomms3123

When proteins tagged with ubiquitin bind to the proteasome, the ubiquitin tag is removed and the proteins are broken down into smaller pieces

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis